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At approximately 3.15pm on Friday 15 November police were called to reports of a collision involving a pedestrian and a car.
The road is closed on the westbound carriageway from the Greystones roundabouts to Ormesby Bank with motorists advised to avoid the area and to use alternative routes.
A man has been arrested in connection with driving offences.
Anyone who has information relating to the collision or has dash cam footage is asked to call Cleveland Police on 101 or visit the website quoting reference number 218779.