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At 9pm on Thursday 21 November police received reports of a stabbing outside of a property on Lealholm Walk.
A 34-year-old man was taken to James Cook University Hospital by ambulance and sadly died a short time later.
His family has been informed and are being supported by specialist officers.
An investigation is now underway, and a police cordon is in place.
A 33-year-old woman from Middlesbrough has been arrested on suspicion of assisting an offender and is currently in police custody for questioning.
Detectives are appealing for anyone with information, dash cam or door-bell footage that could assist with their enquiries.
Senior Investigating Officer Matt Hollingsworth, from Cleveland Police’s Homicide and Major Enquiry Team (HMET), said: “While we have extensive enquiries ongoing I am keen to hear from anyone who was in the area around the time of the stabbing and have either witnessed what took place or has information.
“I would also encourage anyone with information, CCTV or dash cam footage to get in touch.
“I understand there will be concern in the local community and I want to take this opportunity to reassure residents that we will be working around the clock to identify and detain the person responsible.
“There will be an increased police presence with patrols in the area for your reassurance and I would encourage anyone who has concerns to speak to an officer.”
If you have information, please call Cleveland Police on 101 quoting reference number 222453 or visit the website. All footage can be uploaded via this link.
If reticent to come forward, please contact Crimestoppers anonymously on 0800 555 111 or visit their website.